Abstract
We describe the clinical and laboratorial features of oral candidiasis in 66 HIV-positive patients. Polymerase chain reaction-based techniques were performed for differentiation of Candida spp. isolated from patients at a public teaching hospital in Midwest Brazil. Oral lesions, mainly pseudomembranous, were significantly related to higher levels of immunosuppression. Of 45 Candida isolates, 66.7% were C. albicans. Most of the isolates were susceptible to the antifungal drugs tested. Oral lesions were associated with higher immunosuppression levels. Lower susceptibility to antifungals by non-albicans isolates supports the importance of surveillance studies using susceptibility tests to aid in the treatment.
Highlights
We describe the clinical and laboratorial features of oral candidiasis in 66 human immunodeficiency virus (HIV)-positive patients
Introduction: We describe the clinical and laboratorial features of oral candidiasis in 66 HIV-positive patients
Polymerase chain reaction-based techniques were performed for differentiation of Candida spp. isolated from patients at a public teaching hospital in Midwest Brazil
Summary
We describe the clinical and laboratorial features of oral candidiasis in 66 HIV-positive patients. Lower susceptibility to antifungals by non-albicans isolates supports the importance of surveillance studies using susceptibility tests to aid in the treatment. According to a previous study, variations in the clinical aspects of oral candidiasis have been associated with the progression of HIV infection as the CD4+ T-lymphocyte counts decrease[11].
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