Clinical and Instrumental Assessment of the Intestinal State in Children with Respiratory Pathology and Correction of the Revealed Violations

Abstract

The need for frequent and long-term use of antibiotic therapy for respiratory pathology of bacterial origin often leads to the development of the intestinal microflora disorders and requires the inclusion of probiotics in treatment regimens. Probiotics containing Bacillus clausii have proven themselves in the treatment of antibiotic associated diarrhea.The objective: to assess the state of the intestine according to clinical data and the results of hydrogen breath test with lactulose in children with acute respiratory diseases and the effectiveness of the revealed violations correction by adding probiotic containing B. Clausii to the complex therapy.Materials and methods. Under the supervision there were 38 children of 4–10 years old, who in the course of antibiotic therapy of acute respiratory diseases were added probiotic containing B. Clausii (Probiz kids). In the І group of the study (20 children), probiotic was used simultaneously with antibiotic therapy for 7–10 days course. The ІІ group was formed by 18 children, for 7–10 days they received Probiz kids after completing a course of antibiotics. At the beginning of treatment, at 10–12 and for 25–30 days from the start of therapy, the presence of intestinal manifestations was evaluated and a hydrogen respiratory test with a load of lactulose was performed (HRTLL).Results. In the first group, on the 10–12th day from the beginning of the study, the syndrome of excessive bacterial growth disappeared in half of the children. But among the children of group II, the normalization of indicators in a repeated study of HRTLL did not occur in one child. On the 25–30 day from the start of treatment, the absence of excessive bacterial growth was detected in 80% of children of the first group and 50% of children of the second group.Conclusion. The results of the study indicate that probiotic Probiz kids has a positive effect on the intestinal state in children against the background of antibacterial therapy.