Abstract
Thymus capitatus extract has been considered a promise as antiviral agent against COVID‑19 viruses. We hypothesized that Thymus capitatus components may interact with key protein targets of COVID‑19 (coronavirus 2 (SARS-CoV-2) causing severe acute respiratory syndromes. Molecular docking analysis was carried out using 31 components of Thymus capitatus with SARS-CoV-2 protease enzyme (6LU7) and spike glycoprotein (6VSB). The compounds with the best normalized docking scores to protease enzyme were allo-Aromadendrene (-6.3 kcal/mole), spathulenol (-6.6 kcal/mole) and ledene (-6.8 kcal/mole). The best docking ligands for spike glycoprotein were allo-Aromadendrene (-6.6 kcal/mole), spathulenol (-6.6 kcal/mole) and ledene (-7.3 kcal/mole). All Thymus capitatus components may act synergistically to produce the therapeutic action. Thymus capitatus components may potentiate the effect of prednisolone, azithromycin and other medicines used to treat COVID-19 patients.
Highlights
Pulmonary carcinosarcoma is a rare and highly malignant lung neoplasm characterized by a biphasic histopathological pattern consisting of both epithelial and sarcomatous components (1-6)
We have looked at her quality of life with having treatment and the increased survival benefit that some patients would have if they respond to chemotherapy
Carcinosarcoma is a malignant tumor that consists of a mixture of NonSmall Cell Cell Lung Cancer (NSCLC) and sarcoma-containing heterologous elements
Summary
Ahmed S Ali MD1 and Hassan Shikhrakab2 1Medical oncology consultant, Bradford Royal Infirmary, Yorkshire, UK. 2Medical oncology consultant, Royal Blackburn Hospital, Lancashire, UK. *Corresponding Author: Ahmed S Ali, Medical oncology consultant, Bradford Royal Infirmary, Yorkshire, UK. Ahmed S Ali MD1 and Hassan Shikhrakab2 1Medical oncology consultant, Bradford Royal Infirmary, Yorkshire, UK. *Corresponding Author: Ahmed S Ali, Medical oncology consultant, Bradford Royal Infirmary, Yorkshire, UK. Received date: December 31, 2020; Accepted date: January 25, 2021; Published date: January 28, 2021
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