Abstract
The association of pertussis with various respiratory infections in children is the leading factor determining the complicated course and unfavorable outcome of the disease.Objective. To analyze clinical and immunological features of the combined course of pertussis and rhinovirus infection.Children characteristics and research methods. The authors observed 20 patients: 10 (50%) children were under the age of 1 year, 5 (25%) children of 1–3 years old, 3 (15%) children of 4–6 years, 2 (10%) children of 7 -14 years old.Results. The rhinovirus infection developed mainly at 1-2 weeks of illness in 18 (90%) children. Bronchitis developed in 11 (55%) children, pneumonia – in 4 (20%). Special attention was drawn to the low content of NK cells in 82.4% of patients when assessing the subpopulation composition of lymphocytes. The cytokine profile was characterized by a low level of interferon-gamma and interferon-alpha production – in 94.4 and 61.1% of patients, respectively.Conclusion. The combination of pertussis and rhinovirus infection in children contributes to the uneven course of the disease, the frequent development of bronchopulmonary complications.
Highlights
The association of pertussis with various respiratory infections in children is the leading factor determining the complicated course and unfavorable outcome of the disease
The authors observed 20 patients: 10 (50%) children were under the age of 1 year, 5 (25%) children of 1–3 years old, 3 (15%) children of 4–6 years, 2 (10%) children of 7 -14 years old
Special attention was drawn to the low content of NK cells in 82.4% of patients when assessing the subpopulation composition of lymphocytes
Summary
Клинико-иммунологические особенности сочетанного течения коклюша и риновирусной инфекции у детей. Анализ клинико-иммунологических особенностей сочетанного течения коклюша и риновирусной инфекции. Для цитирования: Попова О.П., Бляхер М.С., Федорова И.М., Котелева С.И., Капустин И.В., Драчева Н А., Вартанян Р.В., Бунин С.В. For citation: Popova O.P., Blyakher M.S., Fedorova I.M., Koteleva S.I., Kapustin I.V., Dracheva N.A., Vartanyan R.V., Bunin S.V. Clinical and immunological features of the combined course of pertussis and rhinovirus infection in children. Клинико-иммунологические особенности сочетанного течения коклюша и риновирусной инфекции у детей инфекциями [4,5,6,7]. Исследования по клинико-иммунологическим сопоставлениям при ассоциации коклюша с риновирусной инфекцией не проводились. Цель работы: изучение клинико-иммунологических особенностей коклюша при ассоциации с риновирусной инфекцией у детей
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