Abstract
The aim of the study is to study the cytokine profile in HIV-infected women with acute vaginitis against the background of complex conservative treatment. Materials and methods of research 55 women aged from 25 to 55 years with acute vaginitis were under our supervision. All women were surveyed for the period from 2018 to 2020, of which 35 women with HIV infection, which constitutes the main group, and 20 women without HIV infection, which constitutes the control group. In all female patients, cytokines (to determine inflammatory processes) (IFNγ, IL-17) were determined in the peripheral blood serum. IFNγ, IL-17 were determined by enzyme-linked immunosorbent assay using test systems "Vector-Best" of the Russian Federation. Results and discussion: the ratio of IFNγ / IL-17 (pro-inflammatory / anti-inflammatory cytokines or Th1 / Th2) in HIV-uninfected women was 2.2. In the presence of a pronounced inflammatory process, that is, in HIV-uninfected women, this indicator was 0.96. After carrying out immunocorrective treatment using Immun-5 (The drug is a balanced mixture of natural biologically active substances, the action of which is aimed at activating the body's immune system. The drug increases the body's resistance in inflammatory diseases. An effective remedy for HIV / AIDS, hepatitis and tuberculosis. 1 capsule 2 times a day for 60 days The drug manifests its effects primarily through the effect on the endogenous interferon system and on the expression of cytokines functionally coupled with interferons - IL-2, IL-4, IL-6, IL-10 and IL-17). In the examined HIV-infected women with nonspecific vaginitis, IFNγ approached the control values, the content of IL-17, and after treatment did not normalize, remaining 5.5 times higher than in HIV-uninfected women in the control group, the ratio of IFNγ / IL-17, in HIV-infected women of the main group, after treatment this indicator decreased to 0.42. Conclusion: The improvement in the clinical condition of HIV-infected women, along with the suppression of the level of the pro-inflammatory cytokine IFNγ, was accompanied by the disappearance of signs of inflammation of the genitalia, an improvement in the general condition of HIV-infected women.
Highlights
The problem of infection in women caused by the human immunodeficiency virus (HIV infection) has been studied in obstetrics and gynecology in Uzbekistan since the early 90s
The Swiss Commission on acquired immunodeficiency syndrome (AIDS) (Eidgenossische Kommission fur AIDS-Fragen, EKAF) suggested that the probability of transmission of HIV infection as a result of sexual contact with HIVinfected patients who receive ART and in whom the level of HIV RNA in blood plasma persists for 6 months should be considered negligible below the detection threshold, if they strictly adhere to the order of taking medications, are regularly observed by a doctor and they do not have any symptoms of other sexually transmitted diseases, and allow them to have unprotected sex [3]
Sick women received traditional antibacterial, anti-inflammatory and local therapy in a hospital setting, immunocorrection was prescribed, for which the domestic drug Immun-5 was used (The drug is a balanced mixture of natural biologically active substances, the action of which is aimed at activating the body's immune system. body resistance in inflammatory diseases.Effective remedy for HIV / AIDS, hepatitis and tuberculosis.Application of 1 capsule 2 times a day for 60 days.The drug manifests its effects primarily through the effect on the system of endogenous interferons and on the expression of functionally associated interferons of cytokines - IL-2, IL-4, IL-6, IL-10 and IL-17)
Summary
The problem of infection in women caused by the human immunodeficiency virus (HIV infection) has been studied in obstetrics and gynecology in Uzbekistan since the early 90s. Some researchers consider the level of HIV RNA to be the determining factor in the transmission of the virus This fact served as the reason for a close study of the likelihood of HIV infection during sexual intercourse without the use of contraceptives and initiated a dispute about the possibility of “safe” unprotected sex with people who are HIV-seropositive. The Swiss Commission on AIDS (Eidgenossische Kommission fur AIDS-Fragen, EKAF) suggested that the probability of transmission of HIV infection as a result of sexual contact with HIVinfected patients who receive ART and in whom the level of HIV RNA in blood plasma persists for 6 months should be considered negligible below the detection threshold, if they strictly adhere to the order of taking medications, are regularly observed by a doctor and they do not have any symptoms of other sexually transmitted diseases, and allow them to have unprotected sex [3]. According to EKAF, this recommendation will reduce fears of HIV transmission through sexual intercourse and allowing normal sex life for both HIV-positive and non-HIV-infected people
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