Clinical and immunologic profile of children and adolescents submitted to cow milk oral immunotheray (OIT)

Abstract

Results The mean age was 8.73 years (min: 4, Max: 19), and 9 were females. The symptoms started before 1 year old in 93% of the sample and in 50% before 6 months. Urticaria was the most frequent manifestation in the 1st contact (60%), some progressing to anaphylaxis: the initial event in 40% of cases. Half of the patients responded to minimal amounts of LV, mainly (60%) in raw state. Symptoms appeared in less than 1 hour in 96%. Until the beginning of treatment 73% have had 1-5 episodes of anaphylaxis. About 75% of patients have associated respiratory allergy and 33% had some anaphylactic event in the last 12 months. The specific IgE levels were elevated in 93% of the sample: For full LV the mean level was 50.2 KU/L and the median 41 KU/L (Min: 1.4 KU/l and Max: >100 KU/L); for casein, the mean was 40 KU/L, and the median 28.4 KU/L (0.8 >100). For a-lacto albumin and b-lacto globulin, these values were respectively: 23.1 KU/L, 12.1 KU/L (0.4 82) and 9.94 KU/L, 4:46 KU/L (0.7 31.4).