Abstract
Two patients with reticulum cell sarcoma and one with chronic lymphocytic leukemia and macroglobulinemia were found to have I gM (λ) cold agglutinins; in two the agglutinins were directed against the antigen i and in one against the antigen I. In one patient the 19 S cold agglutinin was cryoprecipitable; the supernatant contained also a 7 S IgM M component of faster mobility devoid of cryoprecipitability and of cold agglutinin activity. In another patient, with high serum viscosity, the cold agglutinin activity was found in three IgM (λ) M components with sedimentation velocities of 7.7 S, 11.5 S, and 19.0 S. The present cases, and those previously reported, support the view that IgM cold agglutinins with lambda light chains are rarely directed against the I antigen. They are frequently cryoprecipitable, and are often found in malignant conditions. Such agglutinins thus differ markedly from cold agglutinins with kappa light chains.
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