Clinical and imaging characteristics of primary hepatic sarcomatoid carcinoma and sarcoma: a comparative study

Dongli Shi,Hongjun Li,Jun Sun,Liang Ma,Jing Chang

doi:10.1186/s12885-020-07475-z

Dongli Shi, Hongjun Li + Show 3 more

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https://doi.org/10.1186/s12885-020-07475-z

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Journal: BMC Cancer	Publication Date: Oct 9, 2020
Citations: 8	License type: open-access

Affiliation: Beijing YouAn Hospital, Capital Medical University

Abstract

BackgroundPrimary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS) are rare malignancies with frequent overlap in both the clinic and radiology. No comparative study of these tumors for the restricted cases has previously been undertaken. The purpose of our study was to analyze the clinical and imaging features of PHSCs and PHSs, with an emphasis on particularities and similarities through a comparison of the two tumors.MethodsWe retrospectively analyzed the clinical and imaging features of 39 patients with pathologically proven PHSCs (n = 23) and PHSs (n = 16) from four university centers over a 9-year period from 2010 to 2019. Univariate analyses were performed to determine the consistent and distinctive features.ResultsThe background of chronic hepatitis or cirrhosis was observed with a high frequency in both of PHSCs (73.7%) and PHSs (62.5%). Tumors with a diameter greater than 10 cm were significantly more common in PHSs than PHSCs (p = 0.043) and cystic masses were more detected in PHSs (P = 0.041). Both PHSCs and PHSs mainly presented hypovascularity (78.3% vs 81.3%). The ring hyper enhancement on the arterial phase (AP) and wash out were more frequently seen in PHSCs and the iso-hypo enhancement on the AP followed persistent or progressive enhancement was more commonly detected in PHSs (all, p < 0.05).ConclusionPHSC and PHS generally present as mass lesions with hypovascularity. The ring hyper enhancement on the AP and wash out favor the diagnosis of PHSC. The large size greater than 10 cm, cystic lesion, iso-hypo persistent or progressive enhancement pattern might suggest the possibility of PHSs.

Highlights

Primary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS) are rare malignancies with frequent overlap in both the clinic and radiology
Primary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS), are rare malignancies accounting for only 0.2% [1] and 1% [2] of primary malignant liver tumors, respectively
Patient characteristics and clinical background The PHSC cohort included 23 patients (20 men, 3 women, median age, 56 years; range, 32–77 years), and the PHS cohort consisted of 16 patients (11 men, 5 women, median age, 58 years; range, 22–75 years)

Summary

Introduction

Primary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS) are rare malignancies with frequent overlap in both the clinic and radiology. The purpose of our study was to analyze the clinical and imaging features of PHSCs and PHSs, with an emphasis on particularities and similarities through a comparison of the two tumors. Primary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS), are rare malignancies accounting for only 0.2% [1] and 1% [2] of primary malignant liver tumors, respectively. The PHSC and PHS have many overlapping features in imaging as well as clinical and pathological findings [4,5,6], but their treatment modalities may be different, even though the most optimal therapy still awaits further evidence, due to the dearth of available information caused by their rarity. An accurate diagnosis is crucial for determining therapeutic planning

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