Clinical and histopathological features of adenoid cystic carcinoma from major salivary gland in ’National Institute Of Neoplastic Diseases’ from Lima, Peru

Abstract

Objectives To review clinical and histopathological features of 9 Peruvian patients in ’National Institute of Neoplastic Diseases’ from Lima, Peru, with adenoid cystic carcinoma of major salivary gland. Method Study subjects were 9 patients who had a diagnosis of adenoid cystic carcinoma of major salivary gland between 2008 and 2014 in the ’National Institute of Neoplastic Diseases’ from Lima, Peru. Electronic medical records were evaluated and slides were reviewed by two pathologists of Head and Neck Pathology. Results Of the 9 patients described in this study, 6 were males (66.6%) and 3 females (33.3%). The median age was 60 years. The most frequent location was in the sub-maxillary gland (55.5%), followed by the parotid gland (44.4%). The predominant histopathological growth pattern was cribriform in 7 cases (77.7%) and solid in 2 cases (22.2%). Perineural invasion was present in 8 cases (88.8%). Conclusions Adenoid cystic carcinoma is a neoplasm with an indolent clinical course and mortality of 35% at 15 years. Stage is the most important prognostic factor; growth pattern-based grade in most series is also important as a prognosticator, being the solid pattern that is related with a more aggressive course. Histopathological features like perineural invasion and predominant tumor growth pattern are important to define diagnosis and prognosis of patients with adenoid cystic carcinoma. To review clinical and histopathological features of 9 Peruvian patients in ’National Institute of Neoplastic Diseases’ from Lima, Peru, with adenoid cystic carcinoma of major salivary gland. Study subjects were 9 patients who had a diagnosis of adenoid cystic carcinoma of major salivary gland between 2008 and 2014 in the ’National Institute of Neoplastic Diseases’ from Lima, Peru. Electronic medical records were evaluated and slides were reviewed by two pathologists of Head and Neck Pathology. Of the 9 patients described in this study, 6 were males (66.6%) and 3 females (33.3%). The median age was 60 years. The most frequent location was in the sub-maxillary gland (55.5%), followed by the parotid gland (44.4%). The predominant histopathological growth pattern was cribriform in 7 cases (77.7%) and solid in 2 cases (22.2%). Perineural invasion was present in 8 cases (88.8%). Adenoid cystic carcinoma is a neoplasm with an indolent clinical course and mortality of 35% at 15 years. Stage is the most important prognostic factor; growth pattern-based grade in most series is also important as a prognosticator, being the solid pattern that is related with a more aggressive course. Histopathological features like perineural invasion and predominant tumor growth pattern are important to define diagnosis and prognosis of patients with adenoid cystic carcinoma.