Abstract
Cardiac myxoma is a major primary heart tumor which often causes unexpected symptoms or sudden death. This present study was designed to investigate its clinical pathological features and biological behavior. A retrospective analysis of the clinical pathologic and immunohistochemical features of 66 cases with cardiac myxoma was conducted. In 66 patients with cardiac myxoma, 61 cases had involvement of the left atrium, one case in both the right ventricular and left atria. The female: male ratio was 2.7:1. Patients had symptoms of blood flow obstruction and systemic alterations with performance of arterial embolization. Tumors were spherical, lobulated or irregular in shape, and soft and brittle. Immunohistochemical markers of vimentin and CD34 in tumor cells were positive. Cardiac myxoma always exists in the left atrium and is more common in women, with diverse clinical manifestations and pathomorphism. Although proliferative activity and the recurrence rate are low, in addition to thorough surgical resection, strengthened review is important for young patients.
Highlights
Due to the tumor size and location in the different chambers of heart, the clinical sign of cardiac myxoma is the obstruction of blood flow resulted in cardiac soufflé, left ventricular or right ventricular dysfunction, orthostatic syncope or sudden death, and embolism performance due to drop of tumor debris and embolus of tumor thrombus (Kuroczyński et al, 2009; Tasoglu et al, 2009)
This study was designed to collect 66 cases with surgical resection of cardiac myxoma and observe these samples from clinical features, pathological and immunohistochemical staining to investigate the features of clinical pathology, tissue and biological behavior
Clinical features The occurrence sites: 61 cases had the myxoma in the left atrium; 3 cases had it in the right atrium; 1 patient had it in the nearly apical part of left ventricular; 1 case had it in the both right ventricular and left atrial
Summary
Due to the tumor size and location in the different chambers of heart, the clinical sign of cardiac myxoma is the obstruction of blood flow resulted in cardiac soufflé, left ventricular or right ventricular dysfunction, orthostatic syncope or sudden death, and embolism performance due to drop of tumor debris and embolus of tumor thrombus (Kuroczyński et al, 2009; Tasoglu et al, 2009). This study was designed to collect 66 cases with surgical resection of cardiac myxoma and observe these samples from clinical features, pathological and immunohistochemical staining to investigate the features of clinical pathology, tissue and biological behavior.
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