Abstract
Primary cutaneous lymphomas, which are diagnosed with only skin involvement, can be of B or T cell origin. Due to their varied origin as well as their diverse presentations, these groups have been divided further into more descriptive and representative groups. The subtypes are primary cutaneous marginal zone lymphoma (PCMZL), primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous diffuse large B cell lymphoma, leg type (PCDLBCL-LT) and intravascular large B-cell lymphoma. Here, we present the cases of three ethnically diverse patients with distinct clinical and histological forms of cutaneous B cell lymphoma.
Highlights
While dermatologic findings may not be what initially come to mind when identifying lymphomas, these neoplasms can and do present cutaneously
Primary cutaneous lymphomas, which are diagnosed with only skin involvement, can be of B or T cell origin, with B cells making up merely 2530% of cases
NonHodgkin lymphoma derived from B cells include diffuse large B cell lymphoma (DLBCL), Burkitt lymphoma, follicular lymphoma, and marginal zone lymphoma, among others.[3]
Summary
While dermatologic findings may not be what initially come to mind when identifying lymphomas, these neoplasms can and do present cutaneously. Patient A A 67-year-old Hispanic male, with a past medical history of coronary artery disease, hypertension, hyperlipidemia, and type 2 diabetes, presented to the dermatology clinic with a two-month history of a red nodule on his left ear. Patient B A 79-year-old African American male, with a history of diabetes and hypertension, presented to the dermatology clinic with a scalp lesion present for the past two years. He noted that the lesion stung upon manipulation. Additional testing can include CD21, CD23, CD43, Cyclin D1, Ki-67, immunoglobulins IgM and IgD, as well as kappa/lambda light chain analysis.[4]
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