Clinical And Hematological Profile Of Febrile Neutropenia In Pediatric Patients Who Suffered From Malignancy At Dr. Soetomo General Academic Hospital Surabaya

Abstract

Background: Febrile neutropenia is a common complication found in the practice of hematology-oncology caused by malignancy and immune-stimulating cytotoxic therapy. The appearance of febrile neutropenia in patients with malignancy often has a negative impact on the patient's prognosis. There has been no research on febrile neutropenia, especially those using data from Dr. Soetomo General Academic Hospital Surabaya until now. This study aims to determine febrile neutropenia's clinical and hematological profile in pediatric patients who suffered from malignancy at Dr. Soetomo General Academic Hospital Surabaya. Methods: A retrospective study using the medical records of febrile neutropenia patients with malignancy at the Division of Hematology-Oncology, Department of Pediatrics, Dr. Soetomo General Academic Hospital Surabaya from January 2018 to December 2019. The descriptive analysis in this study describes the clinical and hematological profile of febrile neutropenia in pediatric patients who suffered from malignancy, including underlying clinical diagnosis, clinical symptoms, clinical signs, and hematological examination results. Results: Thirty febrile neutropenia patients suffered from malignancy. From the data obtained, the most common clinical diagnosis underlying the incidence of febrile neutropenia was acute lymphoblastic leukemia (73%). The most common clinical symptom experienced by patients was fever (100%). The most common clinical sign experienced by patients was anemia (67%). The most common hematological examination results were neutropenia (100%) with absolute neutrophil count <500 cells/?L. Conclusion: Acute lymphoblastic leukemia dominates the clinical diagnosis underlying the development of febrile neutropenia in pediatric patients with malignancy. The most common clinical and hematological profiles were fever, anemia, and neutropenia.