Clinical and genetic features of the formation of concomitant visceral pathology in workers with industrial fluorosis

Abstract

Introduction. The urgency of the problem determines the high level of occupational morbidity in aluminum production workers and the prevalence of somatic pathology, which occupies one of the leading positions in the pathogenesis of fluorosis.The aim of the study is to determine the clinical and genetic features of the nature of concomitant visceral pathology in workers with industrial fluorosis.Materials and methods. A complex of clinical, biochemical, molecular, genetic, and instrumental research methods was used in patients with fluorosis (246 people) and in the control group (106 people).Results. A high frequency of health disorders in workers engaged in the production of aluminum was determined during long-term monitoring. An extended clinical and genetic study of the state of somatic organs in workers with fluorosis and in control is presented. It is revealed that in the group of subjects with proven diagnosis, pathologies concomitant with the main disease were significantly more common: pathologies of musculoskeletal and articular systems, blood circulation, respiratory (rhinitis, chronic, toxic and dust-borne bronchitis, chronic obstructive pulmonary disease), hepatobiliary (steatosis, fluoride hepatopathy), gastrointestinal tract (chronic gastritis, cholecystopancreatitis), renal systems (pyelonephritis, urolithiasis), as well as a combination of several nosologies was in 43%. The association of GG VEGF genotypes with chronic pyelonephritis and TT Il1ß, GSTT 1 0/0 with fluoride hepatosis was revealed in patients with fluorosis.Conclusions. The structure of occupational morbidity in workers of the main professions of aluminum production is dominated by concomitant pathology of functional systems against the background of bone destruction, determined by endogenous factors of the course of metabolic processes of the body.The authors declare no conflict of interests.