Abstract
The work considers and distinguishes the psychopathological symptom complexes of depression in adolescents that are resistant to therapy: anxious, obsessive, behavioral. The level of spontaneous and induced mutagenesis in the blood lymphocytes of adolescents with depression was determined in vitro, which was twice the level of chromosomal aberrations after introducing a mutagen into the culture mixture, which indicates a pronounced individual and group hidden chromosomal instability of patients with depression. The constants of the lack of effectiveness of therapeutic intervention in adolescents with depression were determined (infantilism, personal anxiety, cogni- tive component of depression, noncompliance, addictions, comorbidity of depression with anorexia nervosa, suicidal behavior, recurrent depression, insufficient titration of antidepressant medication, unpleasant side effects of antidepressants).
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