Abstract
A brief report is presented on several lines of study involving solid tumors of the kidney. Wilms' tumors, either immediately after surgery or after freezing preservation, have been transplanted successfully to the chorioallantois of the chick, in combination with normal chick embryonic tissues. The transplanted tumors grew as nodules of anaplastic cells and as neoplastic tubules with various degrees of differentiation. Applying the techniques of renal microdissection to surgical specimens of Wilsm' tumors, we have seen details of tubular structure and branching. A renal cell carcinoma, MDCK, derived from normal dog kidney, grew in culture with one of two patterns of polarization, depending upon the microenvironment of the cells. The implications of these studies for the treatment of clinical cancer is considered.
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