Clinical and experimental Studies on the pathophysiology of liver diseases and intravscular coagulation

Abstract

The clinical and experimental findings related to the mechanism of hepatic cell necrosis in associated with intravascular coagulation were studied.The results and conclusion of our work are summarized as follows.1) Endotoxemia as detected by the Limulus Test, was often found in the patients with fulminant hepatitis and the close correlation found between the development of endotoxemia and the occurence of both renal impairment and intravascular coagulation.2) Experimental endotoxin D. I. C. and liver cell necrosis.E. coli endotoxin was injected into the rabbit portal vein and 24 hours later a ten-fold dose of endotoxin was injected in an ear vein.Extensive liver necrosis was found which was complicated by fibrin microthrombi in the Sinusoid or necrotic area.Similar changes were found in the kidneys and intestinal tract.In fluminant hepatitis complicated by D. I. C., the pathogenesis and haemorrhagic diathesis ressemble that was found in our experimental study.