Clinical and Experimental Studies on Sinobronchial Syndrome

Abstract

From the nasal investigations of 330 cases having chronic bronchitis or bronchiectasis, the chronic paranasal sinusitis was found in 79 or 91.8% of 86 cases having chronic bronchitis, of which bronchogrames revealed slight dilatation of the bilateral basal bronchi, while that was found in 63 or 25. 8 or 244 cascs having bronchiectasis, of which bronchograms demonstrated mostly saccular dilatations. In the cases of the former series the syndrome occured generally in relatively younger childhood and occasionally without the manifestation of preceding respiratory disease, and characterized frequently by obstructive ventilatory insufficiency on the lung function tests and markedly increased hilar marking on x-ray films. Therefore it is more difficult to obtain complete cure of bronchial disorders as well as of paranasal sinusitis in the former series than in the latter.From this clinical observation, it seemed reasonable to recognized a close causality between paranasal sinusitis and swelling of hilar lymphnodes. As an experiment to examine this causality, P32, Au198 or P32-labeled staphylococcus aureus were injected into the maxillary sinus of rabbits and the specific activity calculated one or two hour after the injection was observed to be significantly stronger in the hilar lymphnodes than that in the other regions.