Clinical and epidemiological features in 495 gastroenteropancreatic neuroendocrine patients in Mexico.

Abstract

e15687 Background: Data, incidence and/or prevalence about gastroenteropancreatic neuroendocrine tumors remains unknown in Mexico. Also there is no evidence about any Mexican multicenter study reporting information such as clinical presentation, diagnostic approach and treatment. The biggest problem is the lack of clinical and therapeutic management results so physicians can validate the proper patient protocols. Methods: To know the clinical, epidemiological and therapeutic characteristics of NET-GEP patients treated at the 5 biggest Concentration Mexican Medical Institutions.This paper was developed with the support of 5 Public Medical Institutions: Mexican Social Security Institute (IMSS), Institute for Social Security and Services for State Workers (ISSSTE), Secretary of the Mexican Navy, Petroleos Mexicanos (PEMEX), Ministry of Public Health 495 Patients from 6 hospitals where included: Oncology Hospital, CMN XXI Century, Hospital No. 25 25, Monterrey IMSS, National Cancer Institute (INCAN), National Medical Center November 20, Naval General Hospital of High Specialty and Private Institutions. This was a observational and retrospective academic paper . Results: :Of 495 patients, 59.7% (296) were women and 40.32% (200) were men, 26% of them had around 50 years old. Diagnosis symptoms included: abdominal pain 47.27% (234), gastrointestinal bleeding 18.58% (92) no-predominant symptoms 28.88% (143). Around 32.25% (160) had Carcinoid syndrome and 67.74% (336) were nonfunctioning. The predominant location was pancreas 33.27% (165) and stomach 28.02% (139). 36% resulted circumscribed neoplasia (179), features polypoid 26% (129) and infiltrative 15% (73). The size was > 2cm in 49% (242) > 1-2cm: 36% (180) 0.5 to 1 cm 9% (45) < 0.5 cm 6% (29). Grade: GI 64% (316), GII 13% (66), GIII 23% (114). Metastasis positive ganglioanres (6%) (31), negative (94%) (465). Only seven cases extra nodal metastases (liver (3), lung (2), spleen (2)) Conclusions:This is the first multi-center study in Mexico. Which reflects the clinical characteristics of the NET_GET. The results differ in their epidemiology from that reported in other countries. However, the clinical and therapeutic results are very similar.