Abstract
Purpose. To evaluate clinical and epidemiological features of neonatal sepsis and assess the impact of organ dysfunction on its outcome.Characteristics of children and research methods. The authors carried out a retrospective analysis of 66 patients with neonatal sepsis hospitalized to the neonatal intensive care unit of the Kazan City Children’s Hospital No. 1 from 2013 to 2017. The diagnosis was based on the development of a systemic inflammatory response syndrome, an increase in C-reactive protein concentration in the blood more than 1 mg/dl, the presence of one or more foci of infection, the development of organ dysfunction and the isolation of the microorganism from venous blood. Bacteremia was a mandatory inclusion criterion.Results. In the most cases (54.5%) neonatal sepsis was caused by gram-negative bacteria. 41 and 4.5% of cases were caused by gram-positive bacteria and fungi, respectively. Among the gram-negative bacteria, the main causative agents of sepsis were Klebsiella pneumoniae (27 cases, 41%), among the gram-positive bacteria –staphylococci (24 cases, 36.5%). Fungal sepsis was caused by Candida kruzei (2 cases) and Candida albicans (1 case). In 11 (17%) cases there was a dysfunction of a single organ, in 31 (47%) cases – dysfunction of 2 organs and in 24 (36%) cases – dysfunction of more than 2 organs. The most common impairments were respiratory dysfunction (86%) and hemostatic disorders in the form of thrombocytopenia (58%). Neonatal sepsis was fatal in 11 (17%) cases. It was found that the multiple organ dysfunction was associated with a risk of death (odds ratio – OR = 29.3; 95% CI 3.4–249.7). Among the signs of organ dysfunction, coma (OR = 30.8; 95% CI 3.0–316.6), elevated blood lactate level of more than 5 mmol/l (OR = 22.1; 95% CI 3.5–139,6) and a low platelet count of less than 50 · 109/l (OR = 5; 95% CI 1.2–21.3) had the prognostic significance.Conclusion. Modern neonatal sepsis has a diverse etiology with gram-negative bacteria as causative agents in half of the cases. Despite modern treatment methods, neonatal sepsis remains a formidable infectious pathology. The risk of fatal outcome is associated with organ dysfunction. Coma, elevated blood lactate level and severe thrombocytopenia are the most significant predictors of fatal outcome in neonatal sepsis.
Highlights
Кошкина Анастасия Дмитриевна – студент VIкурса педиатрического факультета Казанского государственного медицинского университета Хасанова Гульшат Рашатовна – д.м.н., доц., зав. кафедрой эпидемиологии и доказательной медицины Казанского государственного медицинского университета 420012 Казань, ул
The authors carried out a retrospective analysis of 66 patients with neonatal sepsis hospitalized to the neonatal intensive care unit of the Kazan City Children’s Hospital No 1 from 2013 to 2017
In the most cases (54.5%) neonatal sepsis was caused by gram-negative bacteria. 41 and 4.5% of cases were caused by gram-positive bacteria and fungi, respectively
Summary
Клинико-эпидемиологические особенности и органная дисфункция при неонатальном сепсисе. Clinical and epidemiological features and organ dysfunction in newborns with neonatal sepsis. Изучение клинико-эпидемиологических особенностей неонатального сепсиса и оценка влияния на исход заболевания органной дисфункции. Для цитирования: Хаертынов Х.С., Анохин В.А., Халиуллина С.В., Любин С.А., Донцова Н.В., Королева П.В., Кошкина А.Д., Хасанова Г.Р. Кошкина Анастасия Дмитриевна – студент VIкурса педиатрического факультета Казанского государственного медицинского университета Хасанова Гульшат Рашатовна – д.м.н., доц., зав. For citation: Khaertynov Kh.S., Anokhin V.A., Khaliullina S.V., Lubin S.A., Dontsova N.V., Koroleva P.V., Koshkina A.D., Khasanova G.R. Clinical and epidemiological features and organ dysfunction in newborns with neonatal sepsis. Неонатальный сепсис – инфекционная патология новорожденных детей, актуальность которой не снижается все последние годы [1, 2]. Цель исследования: оценка возможных клинико-эпидемиологических особенностей неонатального сепсиса и влияния органной дисфункции на исход заболевания
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