Clinical and epidemiological characteristics of catheter-associated bloodstream infections in patients with hematological profile

Abstract

Patients with hemoblastosis, especially recipients of hematopoietic stem cells, are the most immunocompromised group of patients, especially during prolonged episodes of drug-associated granulocytopenia. The aim of the study . To characterize catheter-associated bloodstream infections in patients with hematological profile. Materials and methods . During June to October 2017, catheter-associated bloodstream infections were detected in six patients in the oncogematology department. Results and discussion . All patients came from different regions of the Russian Federation. The diagnosis of infectious complication: catheter-associated bloodstream infection was established only in 33.3 %. When determining laboratory markers of sepsis, high numbers of procalcitonin were observed in 50.0 % of patients, presepsin in 100.0 The growth of the bacterium Burholderia cepacia was observed in both central venous catheters (CVCs) and blood taken from CVCs. Phentotypically, all isolated cultures of Burholderia cepacia can be divided into three types: pan-resistant; polyresistant; polyresistant, but keeping sensitivity to co-trimoxazole. Multilocus sequencing of their DNA was carried out. The same sequence type was found in four patients. Given that the patients came from different regions, had not previously been in the same medical organization, care for CVC in the department of oncogematology was carried out by the same medical staff it can be assumed that four cases were caused by the same hospital strain Burkholderia cepacia.