Abstract
The aim of the present work was to perform clinical and neurophysiological assessment of the rates of neuromental development during the first year of life in preterm neonates with cerebral ischemia grade II–III, allowing for the effects of treatment with Cytoflavin and resuscitation measures. A total of 120 children with gestational ages of 28–36 weeks and body weights of 1060–3150 g were studied. The study group included 61 children whose complex treatment included Cytoflavin at a dose of 2 ml/kg/day i.v. for five days. The control group consisted of 59 patients who received basal treatment without Cytoflavin. Follow-up to a corrected age (CA) of one year included assessment of overall condition and neurological status (using a quantitative assessment of postural muscle tone on the INFANIB scale, psychomotor development on the BSID-II scale, and the functional state of the CNS by computerized electroencephalography by monitoring of physiological sleep). The results demonstrated faster normalization of all study measures of development in children receiving Cytoflavin in their complex treatment as compared with the control group.
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