Abstract
Hemolytic-uremic syndrome is a serious problem in pediatrics and pediatric nephrology. Hemolytic-uremic syndrome is one of the leading causes of acute kidney injury with potential transformation into terminal chronic kidney disease. Currently, the endothelial dysfunction is strongly associated with changes in the serotonergic system in the pathogenesis of hemolytic-uremic syndrome. There are few studies that have revealed an increase in the blood plasma serotonin concentration in children with hemolytic-uremic syndrome, but its role in the pathogenesis of chronic kidney disease has been insufficiently studied. The progressive course of hemolytic-uremic syndrome, up to the terminal stage of renal failure, requires the search for markers of renal tissue damage as prognostically significant factors for the development of nephrosclerosis, which is of particular importance for optimizing the management of such children.
Highlights
Гемолитико-уремический синдром представляет собой серьезную проблему в педиатрии и детской нефрологии, являясь одной из ведущих причин острого повреждения почек с потенциальной трансформацией в терминальную хроническую болезнь почек
Hemolytic-uremic syndrome is a serious problem in pediatrics and pediatric nephrology
The endothelial dysfunction is strongly associated with changes in the serotonergic system in the pathogenesis of hemolytic-uremic syndrome
Summary
Гемолитико-уремический синдром представляет собой серьезную проблему в педиатрии и детской нефрологии, являясь одной из ведущих причин острого повреждения почек с потенциальной трансформацией в терминальную хроническую болезнь почек. Клинико-диагностическое значение дисфункции эндотелия и уровня серотонина в крови при гемолитико-уремическом синдроме у детей. Шига-токсин-ассоциированная форма болезни составляет 90% случаев гемолитико-уремического синдрома у детей и служит самой частой причиной острого повреждения почек в детском возрасте.
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