Clinical and Biochemical Profile of Antenatal Women Suffering from Hypertensive Disorders of Pregnancy Attending A Tertiary Care Health Institution

Abstract

Background: Hypertensive disorders of pregnancy are a major cause of both maternal and foetal morbidity and mortality. Although the much studied phenomenon but yet much is to be learnt about the disease, etiology, pathogenesis, clinical course as well as the complications. The present study was conducted with an objective to determine the clinical and biochemical profile of such disorders. Methods: The present study is a sub-part of a case control study conducted among 180 pregnant women (90 cases and 90 controls) in Kamla Nehru State Hospital for Mother and Child, IGMC Shimla, Himachal Pradesh. Clinical, biochemical and blood pressure parameters of all the participants were documented for the study purpose. Results: Adverse findings in all aspects were seen more often in cases than in normotensives. All non-exposed had systolic and diastolic blood pressure and in normal range. Odoema, pallor and cyanosis were more likely to be seen in hypertensives than controls. Liver function tests, renal function tests and platelet counts were deranged more often in cases than controls. Hyperhomocysteinemia was more commonly encountered among the cases of pre-eclampsia and eclampsia. Fundus examination revealed worse status in hypertensives. Conclusion: The study associates pregnancy induced hypertensive disorders and adverse biochemical, clinical and lab parameters as highlighted by vast literature. Timely screening of such parameters can definitely aid in achieving better maternal and foetal outcomes. Incorporation of homocysteine analysis in routine strategy can definitely strengthen the maternal health care.