Abstract
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Highlights
Sickle cell anemia (SCA) is an autosomal recessive genetic disorder caused by a defect in the HBB gene which codes for hemoglobin ß chain [1, 2]
This study selectively investigated some of the established markers of disease severity due to limited resources, the pattern of the other markers in these patients is not known
Frequent episodes of vaso-occlusive crisis, dactylitis in infanthood, and a high total bilirubin were the most common markers of disease severity identified in this study
Summary
Sickle cell anemia (SCA) is an autosomal recessive genetic disorder caused by a defect in the HBB gene which codes for hemoglobin ß chain [1, 2]. There are documented established markers (indices) of disease severity in patients with sickle cell anemia (SCA) and they determine the course of the disease. This study investigated the pattern and prevalence of some of these markers of disease severity in adult patients with SCA in steady state attending the hematology clinic of a federal tertiary teaching hospital in Ile-Ife, Nigeria. Conclusion: Markers of disease severity were identified in the patients with SCA in this study. There is a need to pay more attention to these patients by following them up more closely
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