Abstract
ObjectiveThis study evaluated the efficacy of NitrAdineTM-based disinfecting cleaning tablets for complete denture, in terms of denture biofilm removal and antimicrobial action. Material and methodsForty complete denture wearers (14 men and 26 women) with a mean age of 62.3±9.0 years were randomly assigned to two groups and were instructed to clean their dentures according to two methods: brushing (control) - 3 times a day with denture brush and tap water following meals; brushing and immersion (experimental) - brushing the denture 3 times a day with denture brush and tap water following meals and immersion of the denture in NitrAdineTM-based denture tablets (Medical InterporousTM). Each method was used for 21 days. Denture biofilm was disclosed by a 1% neutral red solution and quantified by means of digital photos taken from the internal surface before and after the use of the product. Microbiological assessment was conducted to quantify Candida sp. ResultsAn independent t-test revealed a significant lower biofilm percentage for the experimental group (4.7, 95% CI 2.4 to 7.9) in comparison with the control group (mean 37.5, 95% CI 28.2 to 48.1) (t38=7.996, p<0.001). A significant reduction of yeast colony forming units could be found after treatment with Medical InterporousTM denture tablets as compared to the control group (Mann-Whitney test, Z=1.90; p<0.05). ConclusionThe present findings suggest that NitrAdineTM-based disinfecting cleaning tablets are efficient in removal of denture biofilm. In addition, a clear antimicrobial action was demonstrated. Therefore, they should be recommended as a routine denture maintenance method for the prevention of the development of microbial biofilm-induced denture stomatitis.
Highlights
Denture-induced stomatitis is an inflammatory lesion of the denture bearing mucosa that affects approximately 50% of patients wearing maxillary complete dentures35, and has a multifactor etiology
The data were transformed to their square root prior to the analysis to obtain homogeneity of the variances
Of yeast obtained for the control group (CG) and for WKH H[SHULPHQWDO JURXS 0, $ VLJQL¿FDQW UHGXFWLRQ of yeast cfu could be found after treatment with Medical InterporousTM denture tablets as compared to the control group
Summary
Denture-induced stomatitis (atrophic chronic candidiasis) is an inflammatory lesion of the denture bearing mucosa that affects approximately 50% of patients wearing maxillary complete dentures, and has a multifactor etiology. (I¿FDF\ FOLQLFDO DQG PLFURELDO RI 1LWU$GLQH70-based disinfecting cleaning tablets in complete denture wearers dentures or patients with metabolic diseases, such as diabetics, organ transplant patients, cancer patients or patients on chronic antibiotic treatment have an increased risk for developing oral candidiasis. Even respiratory pathogens that are uncommon LQ WKH RUDO ÀRUD KDYH EHHQ LVRODWHG IURP GHQWXUHV including Escherichia coli, Klebsiella pneumoniae, MRSA or methicillin-resistant Staphylococcus aureus and Enterobacteria. Even respiratory pathogens that are uncommon LQ WKH RUDO ÀRUD KDYH EHHQ LVRODWHG IURP GHQWXUHV including Escherichia coli, Klebsiella pneumoniae, MRSA or methicillin-resistant Staphylococcus aureus and Enterobacteria32 The presence of these bacteria increases the risk of aspiration pneumonia and/or aspiration pneumonitis, in particular when swallowing disorders are observed (e.g.: in patients with neurological disorder including peripheral or central neuromotor disability, such as cerebral palsy, stroke, Parkinson’s disease, Alzheimer’s disease or Down Syndrome). Laboratories AG, Vaduz, Liechtenstein), in terms of GHQWXUH ELR¿OP UHPRYDO DQG DQWLPLFURELDO DFWLRQ LQ denture wearers
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