Clinical and angiographic outcomes of drug eluting stents in native Ostial coronary lesions

Abstract

Objectives The study was designed to evaluate the efficacy and safety of drug eluting stents (DESs) in ostial coronary artery lesions, in terms of early and late restenosis rate. Also, the study was aimed to compare the results of implantation of DES to that of bare metal stents. Background The safety and effectiveness of DESs for the treatment of ostial lesions. Methods We included 177 patients with symptoms subjective of angina pectoris or objective evidence of myocardial ischemia; who underwent percutaneous coronary interventions in 189 ostial lesions using DES. The patients were divided into two groups based on the site of ostial lesion. The incidence of MACE, including death, myocardial infarction (MI), need for repeated revascularization (CABG or angioplasty), were recorded in-hospital and at 12 month. Results The initial procedure was successful in 175 patients (98.8%) in the DES arm. There were no significant major in-hospital complications in the DES group, compared to BMS group which showed 4 cases of in-hospital deaths ( p = 0.017). During follow-up, MACE were significantly less frequent in the DES group compared to the BMS group, including death (0.8% vs. 6.4%, p = 0.004) and need for CABG (1.7% vs. 10%, p = 0.012). Conclusions The main finding of our study is that, implantation of the DES in aorto-ostial lesions appears safe and effective. It is associated with high procedural success rate, low immediate and in-hospital complication rate, and favourable long-term clinical and angiographic outcomes compared to bare metal stents.