Abstract
Diseases of the nervous system occupy the second place among the causes of childhood disability. Perinatal injuries of the nervous system constitute up to 65–75 % of all diseases of the nervous system in childhood and lead to disability in 15–30 % of full-term newborns, 40–60 % of born prematurely.Aim: to provide the clinical-anamnestic characteristics of newborns with hypoxic-ischemic CNS injury.Materials and methods. The study included 100 newborns. The main group – 31 patients with CNS hypoxic-ischemic injury complicated by an infectious process, the comparison group – 35 patients with CNS hypoxic-ischemic injury without the infectious process, the control group – 34 conditionally healthy children born without signs of CNS hypoxic-ischemic injury and inflammatory diseases.In the course of the work, the clinical-anamnestic method and the methods of mathematical statistics were used. Statistical processing of results was performed using license program package Statistica 13.0 (StatSoftInc, serial number JPZ8041382130ARCN10-J).Results. It was found that it is impossible to assess the condition of newborns without taking into account an obstetric history due to the fact that complications of the prenatal period lead to the action of harmful factors of different nature on an immature fetus and can cause severe damage including the development of hypoxic-ischemic brain injury.Conclusions. Prematurely born children with hypoxic-ischemic CNS injury complicated by the infectious process, unlike conditionally healthy prematurely born children, are characterized by low gestational age (29.55 ± 4.20 weeks and 36.0 ± 0.0 weeks, respectively), the prevalence of pathology in the second half of pregnancy and threatened miscarriage. The presence of a complicated obstetric history greatly increases the possibility of hypoxic-ischemic brain injury in newborns, and its infectious-inflammatory complication is more likely to develop in children with low body weight and low Apgar scores. The phenomena of hypoxia, both hypoxic and circulatory, are more common for patients who were born prematurely.
Highlights
Born children with hypoxic-ischemic central nervous system (CNS) injury complicated by the infectious process, unlike conditionally healthy prematurely born children, are characterized by low gestational age (29.55 ± 4.20 weeks and 36.0 ± 0.0 weeks, respectively), the prevalence of pathology in the second half of pregnancy and threatened miscarriage
The presence of a complicated obstetric history greatly increases the possibility of hypoxic-ischemic brain injury in newborns, and its infectious-inflammatory complication is more likely to develop in children with low body weight and low Apgar scores
The first group included 31 patients with hypoxic-ischemic CNS injuries complicated by an infectious process, the second group – 35 patients with hypoxic-ischemic injuries of the CNS without the presence of the infectious process, the third group – 34 conditionally healthy children born without signs of hypoxic-ischemic injuries of the nervous system and inflammatory diseases (Table 1). 5 prematurely born children were included in this group; all these patients were characterized by the absence of neurological pathology and infectious processes
Summary
To provide the clinical-anamnestic characteristics of newborns with hypoxic-ischemic CNS injury
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