Clinical analysis on 15 cases of malignant peripheral nerve sheath tumor

Abstract

[Objective]To explore and analyze the biological characteristics and clinical effect of malignant peripheral nerve sheath tumor.[Methods]15 patients with head and neck malignant peripheral nerve sheath tumor in our department were chosen as observation group.15 patients with head and neck benign neurofibroma were.selected aa control group.Observation group underwent palliative operation+ chemotherapy or radiation treatment while control group underwent corresponding operations.The histopathology,early clinical symptom and survival rate were compared in two groups.[Results]①In observation group,the histopathology such as diffuse growth (14 cases,93.33％),average tumor size (3.6± 0.8cm × 2.0 ± 0.5) and remote hemorrhage (10 cases,66.57％) were higher than those in control group,with statistical significant differences (P＜ 0.05),the observation group was worse than control group.②The early clinical symptoms such as acute pain,dyskinesia and dysesthesia in two groups had statistical significant differences (P＜ 0.05),the observation group was much worse than control group.③There were 6 patients having acoustic neurinoma,4 patients had meningioma and 2 patients had gliocytoma in observation group,and the 1 year survival rate was 73.33/ and 5 year survival rate was 6.67％.While the 1 year survival rate and 5 year survival rate were 100％ and 97.56％ respectively in control group.The differences between two groups was obvious and had statistical significance (P ＜ 0.05).[Conclusion]The malignant peripheral nerve sheath tumor has early obvious clinical symptoms,complicated states of illness,poor prognosis,so enough attention should be paid to its clinical diagnosis. Key words: Malignant peripheral nerve sheath tumor; Neurofibroma; Clinical analysis