Abstract
Objective To analyze the multimodal fundus imaging of vitelliform macular dystrophy.Methods Optical coherence tomography (OCT),fluorescein fundus angiography (FFA) and fundus photograph were carried out to the vitelliform macular dystrophy in 26 patients.Results Two eyes belonged to stage 0,fundus imaging were normal; 5 eyes belong to stage Ⅰ,pigment disorders can be observed in macular,OCT showed small cracks in RPE; 25 eyes belonged to stage Ⅱ:oval yellow lesions could be observed in macular area,FFA showed no fluorescence or weak fluorescence,OCT showed a medium-density reflective region between RPE and photoreceptor layer; 12 eyes belonged to stage Ⅲ,the integrity of the yolk-like lesions was damaged,FFA revealed irregular fluorescence,OCT showed RPE layer thickened,highly reflective substance remained; 4 eyes belonged to stage Ⅳ:fundus showed macular degeneration and RPE atrophy,FFA revealed a clear boundary high fluorescence due to scar staining,fluorescein leakage could be found in choroidal neovascularization,OCT showed thinning neurosensory layers,RPE layer was not continuous.Conclusions Combined use of multiple fundus imaging techniques provide a favorable tool to understand the characteristics of Best macular dystrophy. Key words: Best vitelliform macular dystrophy; Fundus photograph; Fluorescence fundus angiography; Optical coherence tomography
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