Clinical analysis of treatment with granulomatous lobular mastitis by ultrasonography-guided abscess puncture aspiration or drainage combined with local application of triamcinolone acetonide for 46 cases

Abstract

Objective To investigate the effect of the ultrasonography-guided abscess puncture aspiration or drainage combined with local application of triamcinolone acetonide in the treatment of granulomatous lobular mastitis (GLM) . Methods The clinical data of forty-six severe GLM patients from February 2015 to February 2017 were analyzed. Twenty-three patients were treated with the ultrasonography-guided abscess puncture aspiration and irrigation (control group), and the other 23 patients were treated with triamcinolone acetonide injection 40 mg from the pinpoint or a drainage tube into the abscess cavity, pressure dressing, 2 times a week after the routine abscess puncture aspiration and irrigation treatment (observation group). The recovery rate, onset time, hospitalization days and patient satisfaction were compared between two groups, and hormone related adverse reaction of observation group was observed. Results There were 17 cases with effective treatment and 1 cured case in the observation group, while 10 cases with effective treatment, no cured case and 1 case lost in control group, with statistical difference (χ2=5.15, P=0.023). Compared with the control group, the observation group had faster onset time, fewer days of hospitalization, and higher satisfaction of the patients (t=5.81, 5.80, χ2=8.09, P<0.01, <0.01, 0.004). The observation group had no obvious hormone-related adverse reactions, whereas 6 patients in the control group had side effects, which gradually disappeared after the cessation of treatment. Conclusion The ultrasonography-guided percutaneous aspiration and drainage combined with local application of triamcinolone acetonide is a choice for clinical treatment of severe GLM. Key words: Granulomatous mastitis; Carcinoma, lobular; Paracentesis; Triamcinolone acetonide