Clinical analysis of the relationship between primary hepatic cancer and HBV infection

Abstract

Objective To investigate the relationship between primary hepatic cancer（ PHC）and hepatitis B virus （ HBV）. Methods ELISA was used to detect the hepatitis B virus markers（ HBV-M）and hepatitis B virus DNA（ HBV-DNA）in 138 patients with PHC and 130 cases of chronic liver disease,and the results were analyzed. Results Most of cases（57. 25%）showed positive HBsAg,anti-HBe and anti-HBc,followed by positive HBsAg and anti-HBc（21. 01%）, only 19. 57% of the cases showed positive HBeAg,and other expression patterns of PHC HBV-M were few. Ninety-three cases（67. 39%）had HBV-DNA at 10^2 -10^6 copy/ml,indicating that HBV replication played an important role in PHC occurrence. The high-risk age of PHC was 40 to 60 years old（71. 74%）,and the ratio of male to female was 9. 62：1. Conclusions PHC is highly correlated with HBV infection,HBV infection and HBV-DNA replication are the important factors of the development of PHC. The patients with positive HBsAg,anti-HBe and anti-HBc,between 40 and 60 years old,continuously increased HBV-DNA level should be intervened as soon as possible,in order to reduce the risk of PHC occurrence. Key words: Primary hepatic cancer; Hepatitis B virus markers; Hepatitis B virus DNA