Clinical analysis of the patients with single fair cleavage-stage embryo on day 3

Abstract

Objective: This study aimed to explore an appropriate selection for the patients with single fair cleavage-stage embryo on day 3.Methods: This study included 469 fresh transfers and 220 frozen-thawed transfers from January 2014 to June 2016. Furthermore, in 72 patients who have only 4–6 fair embryos (4–5 blastomeres) on day 3, the blastocysts were cultured to day 5 for transfer.Results: In the fresh transfers, the clinical pregnancy rate of 4–5 blastomeres group was significantly lower than 6–7 and 8–10 blastomeres group (5.88 vs. 30.13%, p<.001and 5.88 vs. 26.09%, p < .001). In the frozen-thawed transfers, the clinical pregnancy rate of 4–5 blastomeres group was also significantly lower than 6–7 and 8–10 blastomeres group (10.00 vs. 28.57%, p = .040 and 10.00 vs. 33.33%, p = .005). For the blastocyst transfers derived from fair embryos with 4–5 blastomeres, the clinical pregnancy rate was significantly higher than single and double fair embryo transfers of similar quality (44.44 vs. 7.04%, p < .001 and 44.44 vs. 28.09%, p = .013).Conclusions: For the patients with single fair embryo (6–7 blastomeres or 8–10 blastomeres), transfer at the cleavage stage is feasible. For the patients with single fair embryo (4–5 blastomeres), transfer of single fair embryo at the blastocyst stage or accumulating two fair embryos might be worthy of consideration.