Clinical analysis of stereotactic gamma-ray body radiation therapy for 24 patients with adrenal gland metastases

Abstract

Objective To evaluate clinical efficacy and safety of gamma-knife in the treatment of adrenal metastases.Methods The data from 24 patients with adrenal metastatic carcinoma performed with γ-SBRT were analyzed.A total dose sent 3-5 Gy/fiaction to 50 ％ isodose covering 100 ％ PTV,the radiation dose to adrenal nidus ranged from 40 to 52 Gy,and five times per week.Results The median follow-up time was 28 months,and the follow-up rate was 100 ％.There were 26 lesions.The local lesions response rate was 84.6 ％ (22/26),with complete remission was 53.8 ％ (14/26) and partial was 30.8 ％ (8/26).Local control rate of 1-year,2-year were 100.0 ％ (15/15) and 90.0 ％ (9/10).The overall survival rate of 1-year,2-year and 3-year were 62.5 ％ (15/24),41.7 ％ (10/24) and 18.2 ％ (4/22).6 cases had back pain,2 patients had complete relief of pain,3 patients had pain relief.The majority of radioreactions were Grades 1 to 2 toxicities.Conclusion Gamma knife treatment has yielded good curative effect on adrenal metastatic carcinoma,and adverse reactions are mild. Key words: Gamma knife; Adrenal gland neoplasms; Metastases; Treatment