Clinical analysis of retinopathy of prematurity

Abstract

Objective To observe the prevalence and the risk factors of retinopathy of prematurity (ROP)in premature and low birth weight infants and to investigate the reasonable ROP screening standard methods.Methods Totally 275 premature infants who were less than 37weeks postconceptional age,or birth weight ≤ 2500g who were treated in our hospital.They were screened for ROP until the retina was entirely vas-cularised.Results The prevalence of ROP in our study was 13.82%,the prevalence of ROP in subgroup with birth weight ≤ 1500g(37.84%)was significantly higher than the subgroup with birth weight 1501～2000g (8.06%)and the subgroup with birth weight 2001～2500g(2.24%)(x2=45.357, P= 0.000).There were signifi-cant difference in ROP rate among group(gestional age≤ 30 weeks),group(gestional age 31～32 weeks)and group(gestionai age≥ 33 weeks)(P=0.000).ROP infants had longer time of oxgen supplementation((Z= 5.292, P= 0.000)and more demand of mechanical ventilation(x2= 30.597, P= 0.000).Cases with multiple ges-rational births in ROP group were not significantly different from that in non-ROP group(x2=0.748,P=0.387).ROP was related to gestational age,birth weight,oxygen duration time and the using mechanical venti-lation.Conclusion Shorter gestationai age and lower birth weight and less time of giving oxygen and the using mechanical ventilation may result in higer ROP incidence.Routine screening of fundus in premature infants may be helpful for the early detection of ROP. Key words: Premature infant; Retinopathy; Risk factor