Clinical analysis of pregnancy outcome assisted by in vitro fertilization-embryo transfer between donor and recipient

Abstract

Objective To investigate the clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET) between donor and recipient. Methods Pregnancy outcomes of 31 donors of infertility patients of ovarian hyperresponsiveness and 30 recipients receiving by IVF-ET from January 2011 to December 2016 in the Reproductive Center of Henan Provincial People's Hospital were retrospectively analyzed. Results The implantation rate of frozen-thawed embryo transfer (FET) cycle (52.05% vs. 58.70%), the clinical pregnancy rate (69.23% vs. 73.91%), the live birth rate per transplant cycle (61.54% vs. 65.22%), the cumulative pregnancy rate per oocyte pick-up cycle (87.10% vs. 100.00%), the twin rate (40.74% vs. 48.39%), and the live birth rate (77.42% vs. 96.77%) were slightly higher in donor group than in recipient group, while there were no significant differences (P>0.05). There were no significant differences in implantation rate (58.70% vs. 40.74%), clinical pregnancy rate (76.00% vs. 57.14%), early abortion rate (5.26% vs. 12.50%) and live birth rate per transplant cycle (72.00% vs. 42.86%) between group of 0.05). There were significant differences in cumulative pregnancy rate (100.00% vs. 66.67%) and live birth rate per oocyte pick-up cycle (94.74% vs. 50.00%) (P=0.037, P=0.007). Conclusion Oocyte donation IVF-ET is an effective method to assist infertility patients such as premature ovarian failure, perimenopausal period, chromosomal abnormalities, and repeated failure of IVF-ET. The success rate of pregnancy in the recipients of oocyte is similar to that in the donors. All different age groups of recipients can obtain good pregnancy outcomes, and the young recipients have a higher live birth rate. Key words: Fertilization in vitro; Embryo transfer; Oocyte recipient; Frozen-thawed embryo transfer; Live birth rate