Clinical Analysis of Pregnancy Accompany With Malignant Tumor

Abstract

Objective To investigate the clinical effects of pregnancy accompany with malignant tumor and its impact on mother and fetus. Methods The clinical data of 20 pregnant women accompany with malignant tumor in SUN Yat-sen Memorial Hospital from 2006 to 2011 were analyzed retrospectively. Among them, the tumors associated with pregnancy were breast cancer (6/20, 30.00%), cervical cancer (5/20, 25.00%), liver cancer(3/20, 15.00%), ovarian cancer (2/20, 10.00%), thyroid cancer (2/20, 10.00%), nasopharyngeal carcinoma (1/20, 5.00%), and malignant brain tumor(1/20, 5.00%). The following items were analyzed retrospectively, clinical manifestations, diagnosis, pre- and post-parturition, gestational weeks, delivery methods, birth weight of neonate, Apgar score and abnormality. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of SUN Yat-sen Memorial Hospital, SUN Yat-sen University. Informed consent was obtained from all participates. Results Among 20 cases, six patients(30.00%) opted to therapeutic abortion, four patients(20.00%) received chemotherapy at the second or third trimester, four patients(20.00%) received surgery during pregnancy. Eleven cases(78.57%, 11/14) received cesarean section and 3(21.43%, 3/14) received vaginal delivery at 30+ 5-39 gestation weeks. Neonatal birth weight was (1380-3200)g. There was no neonatal asphyxia and congenital malformation. Conclusions Surgery can be conducted safely during pregnancy. Some chemotherapy drug can be applied in the second and third trimester. The management of tumor associated with pregnancy mainly depends on tumor stage, gestational age and the patient's wishes. Key words: pregnancy; malignant tumor; chemotherapy; surgery