Abstract
(1) Background: We analyzed the duration of persistent subretinal fluid (PSF) and the contributing factors of PSF after pars plana vitrectomy in patients who had a macula with diabetic tractional retinal detachment (TRD). (2) Methods: Forty eyes of 40 patients who had pars plana vitrectomy due to a macula with diabetic TRD, between 2014 and 2020, were retrospectively reviewed. The duration of PSF, as well as relevant ocular and systemic factors, was analyzed. (3) Results: The mean duration of PSF was 4.4 ± 4.7 months. The prevalence of PSF was 75.0% at 1 month, 50.0% at 3 months, 30.0% at 6 months and 10.0% at 12 months after surgery. Blood urea nitrogen, creatinine, and estimated glomerular filtration rate (eGFR) were significantly associated with the duration of PSF in the univariate analysis. In the multivariate analysis, only eGFR was significantly associated with the duration of PSF (β = −0.089, p = 0.030). (4) Conclusion: PSF may persist for more than 12 months in a macula with diabetic TRD after vitrectomy. Moreover, patients with impaired kidney function tended to have a delayed subretinal fluid absorption. Therefore, careful investigation of preoperative systemic conditions, especially kidney function, should be considered before TRD surgery in diabetic patients.
Highlights
The prognosis of proliferative diabetic retinopathy (PDR) is greatly improved in the era of panretinal photocoagulation and anti-vascular endothelial growth factor (VEGF)intravitreal injection [1,2]
This study reports the prevalence of Persistent subretinal fluid (PSF) and analyzes ocular and systemic factors contributing to the duration of PSF after pars plana vitrectomy in patients with PDR 2ac‐
Values are presented as the mean ± standard deviations—blood urea nitrogen (BUN): blood urea nitgogen; eGFR: estimated glomerular filtration rate; HbA1c: Hemoglobin A1c; ILM: internal limiting membrane; PSF: persistent subretinal fluid; SO: silicone oil; SRF: subretinal fluid; VEGF: vascular endothelial growth factor
Summary
The prognosis of proliferative diabetic retinopathy (PDR) is greatly improved in the era of panretinal photocoagulation and anti-vascular endothelial growth factor (VEGF). Pars plana vitrectomy for TRD may still be one of the most complex vitreoretinal procedures. The goals of this surgery are to remove vitreous hemorrhage, reduce the anterior-to-posterior vitreous traction on the retina, and to relieve epiretinal tangential traction on which proliferative tissue grows. Karimov et al [8] analyzed the prevalence of PSF in macula with diabetic TRD after vitrectomy. All cases received pars plana vitrectomy with intraocular tamponade, and no published report elucidated the effect of intraocular tamponade on PSF in diabetic TRD surgery. This study reports the prevalence of PSF and analyzes ocular and systemic factors contributing to the duration of PSF after pars plana vitrectomy in patients with PDR accompanying a macula with TRD.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
