Clinical analysis of early lumbar drainage combined with antibiotic therapy in ventricular peritoneal shunt infection

Abstract

Objective To explore the effectiveness of early lumbar pool drainage combined with antibiotics treatment in remedying ventricle peritoneal shunt infection and the problems needed to be paid attention during the process of treatment. Methods Twenty-two patients with infection after ventricle peritoneal shunt, admitted to our hospital from January 2008 to June 2015, were given lumbar pool drainage combined with antibiotics treatment, including 16 with early lumbar pool drainage combined with antibiotics treatment(3-7 d of infection)and 6 with late lumbar pool drainage combined with antibiotics treatment(8-10 d of infection). The clinical data and treatment efficacy were retrospectively analyzed. Results Bacterial culture of cerebrospinal fluid in the 22 patients indicated negative results in 5, coagulase negative staphylococcus in 10, staphylococcus aureus in two, enterococcus in two and klebsiella bacillus in three; the cure rate of patients with staphylococcus aureus was the lowest(0%); after lumbar pool drainage combined with antibiotics treatment, the cure rate of these patients reached to 72.7%(16/22); the infection of the left 6 patients could not be controlled, and therefore ventriculoperitoneal shunt was removed. The cure rate in patients with early treatment was better than that in patients with late treatment(88% vs. 33%). Conclusion Early lumbar drainage combined with antibiotics can effectively control the ventricle peritoneal shunt infection, avoid risk of second operation and save economic burden. Key words: Lumbar cerebrospinal fluid drainage; Intracranial infection; Ventriculo-peritoneal shunting