Clinical analysis of collagen metabolism disorder and its influencing factors in patients with inguinal hernia

Abstract

Objective To study the clinical expression and metabolism of collagen in patients with inguinal hernia, and to provide evidence for the clinical treatment of inguinal hernia. Methods From June 2012 to June 2017, eighty-nine male patients with inguinal hernia undergoing surgical treatment in Tongcheng People's Hospital of Yingshouyingzi Mining Area were selected, with 48 cases of direct hernia, and indirect hernia in 41 cases. In addition, 40 patients without hernia were selected as the control group. Among the participants in the experiment, regular smokers were 68 cases, including 30 cases of direct hernia group, 24 cases of indirect hernia group, 14 cases in the control group. 61 cases were no frequent smokers. Abdominal rectus and anterior sheath tissue at the end of surgery were collected, collagen immunohistochemical method was used to measure the anterior rectus sheath tissues in typeⅠ and Ⅲ, and to compare the differences between groupⅠ and groupⅢ collagen content. Results TypeⅠ collagen content of direct inguinal hernia group and indirect hernia group was significantly lower than that of the control group, while typeⅢ collagen content was higher than the control group, and collagen ratio of type Ⅰ : typeⅢ in direct and indirect hernia group was lower than the control group, the differences were statistically significant (F=8.053, 7.331, χ2=5.163, P<0.05, <0.05, 0.036). Compared with indirect hernia group, typeⅠ collagen expression was lower than direct hernia group, typeⅢ collagen expression was higher than direct hernia group, typeⅠ : Ⅲ collagen ratio was lower than the hernia group, the difference was statistically significant (P<0.05). TypeⅠ collagen of the smoker group was lower than that in non smoking group, and type Ⅲ collagen expression was higher than that of non smoking group, type Ⅰ: Ⅲ collagen ratio lower than non smokers, the difference was statistically significant (P<0.05). Conclusions The disorder of collagen metabolism in the anterior sheath of the abdominal rectus abdominis in patients with adult inguinal hernia may be an important reason for the morbidity of inguinal hernia. Collagen metabolism disorder in direct type patients is higher than in patients with indirect inguinal hernia. The metabolic disorder of collagen is more frequent in smokers than in non smokers. Smoking is an important factor for the occurrence of inguinal hernia. Key words: Hernia, inguinal; Collagen typeⅠ; Collagen typeⅢ; Metabolic disorder; Rectus abdominis