Abstract

Objective To observe the therapeutic efficiency and associated complications of allogeneic hematopoietic stem cells transplantation (allo-HSCT) for treatment of children with malignant hematological disease.Methods Fifteen children with malignant hematological disease were subjected to allo-HSCT from Jan 2007 to Jan 2013.Among those 15 patients,13 cases were diagnosed as acute leukemia (AL),1 case as chronic myeloid leukemia (CML),and 1 case as myelodysplastic syndrome (MDS-RAEB).The clinical characters of all cases after transplantation were analyzed retrospectively.Results Seven cases survived from 5 months to 6 years after transplantation.Five cases abandoned treatment because of relapse or severe infections.Three cases developed grade Ⅰ acute graft-versus-host disease (aGVHD),three cases developed grade Ⅱ,Ⅲ and Ⅳ aGVHD respectively,and one case died of Ⅳ aGVHD.Two patients experienced extensive chronic graft-versus-host disease (cGVHD),in whom one died of cGVHD,the other suffered with poor quality of life.Conclusions Allo-HSCT is an efficient operation for the treatment of children with hematologic malignancies.Reduction of complications associated with allo-HSCT is the first issue needs to be overcome,meanwhile,it is also important to understand the indications of children allo-HSCT. Key words: Allogeneic hematopoietic stem cells transplantation; Hematological malignancies; Children; Complication; Indication

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