Clinical analysis of 81 premature infants with early-onset sepsis

Abstract

Objective To investigate the prevention and treatment of premature infants with early-onset sepsis. Methods The clinical data, pathogenic bacteria, high risk factors and treatment outcome of 81 premature infants with early-onset sepsis were retrospectively analyzed. Results The incidence of premature infants with early-onset sepsis in hospitalized neonates was 3.82%. The most common pathogens were gram-positive bacteria(64.29%), Staphylococcus aureus was the most common pathogen; Gram-negative bacilli accounted for 29.76%, Escherichia coli was the most common pathogen; Fungi accounted for 6.17%, Candida albicans was the most pathogen. The high risk factors of early-onset sepsis were premature with low birth weight, cesarean section, tracheal intubation, use of PS, prenatal use of hormones and maternal infection. Conclusions The most common pathogens of NICU in premature infants with early-onset sepsis were mainly gram-positive bacteria. So we should strengthen pregnancy management, reduce the invasive operation, standardized aseptic operation, use hormone reasonably and prophylactic antifungal therapy, reduce the occurrence of premature sepsis and its complications. Key words: Premature infants; Septicemia; Pathogen; Drug sensitivity test