Clinical Analysis of 75 Children With Congenital Syphilis

Abstract

Objective To investigate clinical feature of the congenital syphilis (CS) and whether combined with other infections such as TORCH infection and organ damage. Methods From February 2006 to October 2010, 75 cases diagnosed as CS were included into this study. According to whether with or without TORCH infection, which were divided into pure CS group (n=39) and CS combined with TORCH group (n=36). General data of two groups had no significant difference (P>0.05). This study protocol was approred by the Ethical Review Board of Investigation in Human being of this hospital. Informal consent was obtained from guardians of children. The children in the two groups were compared and analyzed in multiple system lesions and laboratory test results, etc.. Results In liver hepato splenomegaly, anemia, thrombocytopenia, elevated transaminases, hypoproteinemia and chest X ray, the difference of the children in group CS and group CS with TORCH infection were statistically significant (P<0.05). Conclusions The incidence of other organ damage in the respiratory system, digestive system, blood system increased significantly, aminotransferase levels increased obviously, the degree of liver damage was more serious in CS children combined with TORCH infection. Key words: newborn; congenital syphilis; TORCH infection; multi-system damage