Clinical analysis of 46 cases of female laryngeal contact granuloma

Abstract

Objective:To investigate the clinical characteristics, diagnosis and treatment of female laryngeal contact granuloma. Method:The clinical data of 46 female patients with laryngeal contact granuloma diagnosed and treated by our clinical team from March 2011 to October 2018 were retrospectively analyzed. Result:The age of the 46 patients ranged from 5 to 58 years old, with an average age of 36.76 years old. The causes of the contact granulomas historically may be the result of intubation in 33 cases, laryngopharyngeal reflux in 8 cases, chronic cough in 2 cases, laryngopharyngeal reflux combined with chronic cough in 2 cases, and voice abuse and excessive clearing of the throat in one case. All patients were followed up for at least half a year, and all of them were cured. Among the 6 patients with large lesions who underwent surgical treatment, 3 relapsed within 3 months, PPI treatment was performed for 2 to 6 months after recurrence, and no recurrence was observed during follow-up, with an average course of treatment of （1.67±2.34） months. All the 11 patients who received corticosteroid injections recovered after 1 to 7 injections, with a median of 3 injections, and an average course of treatment of （2.64±1.69） months. All the 13 patients with oral PPI were cured, with an average course of treatment of （4.15±2.76 ）months; No recurrence was found in the follow-up of 16 patients with conservative treatment under regular observation, with an average course of treatment of （5.88±3.76） months. The difference in cure time between the intervention group （30 cases） and the observation group （16 cases） was statistically significant, and the cure time of the intervention group was shorter than that of the observation group （H=11.902, P=0.008）. Conclusion:Female patients with laryngeal contact granuloma are common after intubation, and various treatments or conservative observation can achieve good results, and treatment intervention may shorten the cure time.