Abstract

Objective To investigate the diagnosis, therapy and prognosis of colorectal neuroendocrine neoplasm (NEN) through a retrospective analysis on the colorectal NEN clinical features. Methods Clinicopathological data of 25 patients with colorectal NEN from January 2006 to January 2015 in Hubei Cancer Hospital were analyzed. Results Three of the 25 cases of NEN occurred in appendix, 3 in ascending colon, 2 in sigmoid colon, 17 in rectum. The NEN were divided into four grades: G1 (11 cases), G2 (3 cases), NEC (8 cases), MANEC (3 cases). Immunohistochemical staining revealed that the positive rates of Syn, CgA and NSE were 96%, 68% and 92% respectively. Liver is the most common place of metastasis in NEN patients. The 5-year survival rate of stage Ⅰ and Ⅲ patients were 100% and 25% respectively, while the 5-year survival rate of stage Ⅱ patients was 50%. The survival time of 2 stage Ⅳ patients was 28 months and 37 months respectively. Conclusions The clinical manifestations of colorectal NEN are of non-special and endoscopic biopsy is the major diagnostic modality. The main method of treatment for colorectal NEN is surgery, and the prognosis was associated with clinical stages and grades. Key words: Colorectal neoplasms; Prognosis; Neuroendocrine neoplasm; Diagnosis

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