Clinical analysis of 19 patients with primary pulmonary non-Hodgkin lymphoma

Abstract

Objective To discuss the diagnosis, treatment and prognostic factors of primary pulmonary non-Hodgkin lymphoma (PPNHL). Methods A retrospective analysis was performed on the clinical data of 19 patients from January 2000 to October 2014, who was diagnosed as PPNHL in Henan Cancer Hospital with complete data. The Kaplan-Meier method and Log-rank test were used in the survival analysis and the difference analysis, respectively. Results There were 13 patients with primary pulmonary mucosa-associated lymphoid tissue (PPMALT) lymphoma in the group and the others were non-PPMALT lymphoma. The 5-year overall survival rate of the 19 patients was 72.3 %, among which patients with PPMALT lymphoma or non-PPMALT lymphoma had statistically significance (83.3 % vs 50.0 %, P= 0.047). Conclusions PPNHL is very rare, lacking specificity of its clinical manifestations and imaging findings. Pathology and immunohistochemistry are important to its diagnosis. Though PPNHL lacks uniform treatment programs, most of them are MALT lymphoma with good prognosis. Key words: Lymphoma, non-Hodgkin; Lung; Diagnosis; Therapy