Clinical analysis of 12 cases of recurrent skull base chordoma

Abstract

Objective To investigate the clinical manifestations, pathological features, treatment and prognosis of recurrent skull base chordoma. Methods A retrospective analysis was made of the clinical data of 12 patients with recurrent skull base chordoma were confirmed by pathology of the 61 patients with chordoma who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2013 to April 2018. Results Among the 12 patients, because of the relevant treatment (7 patients had undergone radiotherapy), 11 patients showed symptoms of cranial nerve damage such as headache and visual function impairment, and the tumors were surgically removed. Five patients underwent total tumor resection, and the remaining 7 patients were partially resected. The positive rate of Ki-67 in 7 patients who had undergone radiotherapy was significantly higher than that in 5 patients without radiotherapy. The follow-up period was 13 to 85 (44.67±26.73) months. Eleven surviving patients were still in the follow-up. Conclusions The main clinical manifestation of patients with recurrent chordoma is cranial nerve injury.Surgery and adjuvant chemoradiotherapy are the first choice in the treatment of recurrent chordoma, which can improve the prognosis of patients to a certain extent. Key words: Skull base chordoma; Recurrence; Clinical manifestation; Pathology; Treatment