Clinical analyses of hematological abnormalities in systemic lupus erythematosus

Abstract

To explore the characteristics of hematological abnormalities in patients with systemic lupus erythematosus (SLE) through retrospective analysis. A total of 445 SLE patients were recruited and divided into 5 groups of low white blood cell, immune thrombopenic purpura, anemia, pancytopenia and control without hematological abnormalities. Among them, 351(78.9%) had hematological abnormalities and 94 (21.1%) without hematological abnormities. The prevalence of anemia, leucocytopenia, thrombocytopenia and pancytopenia were 56.0% (246/445), 27.6%(123/445), 13.5%(60/445) and 8.5%(38/445) respectively. The incidence of renal damage in anemia group was significantly higher than that in control group (P<0.01). SLE patients with hematological abnormalities had lower complement C3 levels (P<0.05) and higher systemic lupus erythematosus disease activity index (SLEDAI) (P<0.01). Anemia is the most common findings in SLE patients with hematological abnormalities who have lower complement C3 levels and higher SLEDAI. Key words: Lupus erythematosus, systemic; Hematology