CLINICAL, AMNESTIC AND IMMUNOLOGICAL PARAMETERS IN HIV-INFECTED PATIENTS WITH GASTROENTEROLOGICAL DISEASES

Abstract

Nowadays the relevance of questions of comorbidity of different pathologies, including HIV infection diseases of the digestive system. Structural and functional changes in HIV infection can occur in various organs of the digestive system: mouth, esophagus, stomach, liver and in the intestine. The aim of the study was to examine features of the social, epidemiologic, somatic and immune status in HIV infected patients with gastroenterological diseases. Materials and methods. The study involved 500 HIV infected patients consisting on the dispensary account in the Center for the prevention and control of AIDS of the Tyumen region. Results. Sex-age structure and epidemiological history among HIV infected patients with gastrointestinal pathology did not differ (p>0,05) of the total cohort of HIV infected Tyumen region — predominance of males, middle-aged with intravenous by HIV infection in the non-medical use of psychoactive substances. The most common gastrointestinal abnormalities in HIV infection are diseases of the gastroduodenal zone (68,2%) and diseases of the bile ducts (31,8 per cent). Indicators CD4, CD8, and LN of HIV infected to determine the diversity and severity of clinical symptoms resulting from lesions of the digestive tract. The prevalence of gastrointestinal disease in HIV infected patients had inverse correlation of medium strength with immunoregulatory index CD4/CD8 (r=-0,537; p<0,05). Conclusion. Pathogenetic defeat of the digestive system in HIV infection may be caused by direct impact of the virus on the gastrointestinal tract and opportunistic infections, and the indirect influence during chronic systemic inflammatory response and immunodeficiency condition, and also result from prolonged administration of drugs.