Clindamycin phosphate, tretinoin with benzoyl peroxide versus clindamycin phosphate and tretinoin combination without benzoyl peroxide for the treatment of acne vulgaris

Abstract

Introduction: Acne vulgaris (AV) is a prevalent skin disorder among adolescents. Affects around 80–90% of adolescents in the Western population. The present study aimed to compare the therapeutic efficacy of Clindamycin phosphate (CLM), Tretinoin (TN) with Benzoyl peroxide (BP) versus clindamycin phosphate and tretinoin combination without Benzoyl peroxide for treatment of AV. Methodology: 250 patients with mild to moderate acne on the face were enrolled in the study and were divided into two groups; group I (n=125); apply CLM 1.2%, TN 0.025%gel with BP 3.75% gel and group II (n=125) apply only CLM 1.2% and TN 0.025% gel without BP 3.75% gel; once daily at night for 4 weeks. The change in acne lesions was recorded every 2 weekly follow-ups using the global acne grading system and non-inflammatory (NI-L), Inflammatory (I-L) lesions count and Investigator's Static Global Assessment grading. Results: The research involved 250 patients split into two groups: 125 patients in group I and 125 patients in group II. After 4 weeks, the group I had a higher mean percent decrease in non-inflammatory, inflammatory, and total lesion count than group II.