Abstract
Twenty-eight patients with anaerobic pleuropulmonary infections were treated with clindamycin alone or clindamycin with gentamicin. Sixteen of the patients presented with pneumonitis, nine with necrotizing pneumonia, and three with lung abscesses. The average length of treatment was 13.8 days, and the duration of temperature after initiation of therapy was 3.1 days. The predominant isolates were anaerobic gram-positive cocci (23 isolates), Bacteroides melaninogenicus (14), Bacteroides fragilis (9), and Fusobacterium nucleatum (11). The most frequent aerobic isolates were alpha-hemolytic streptococci (12), Diplococcus pneumoniae (12), Pseudomonas aeruginosa (9), Klebsiella pneumoniae (7), group A beta-hemolytic streptococci (5), Staphylococcus aureus (9), and Escherichia coli (6). All patients responded to the therapy and were cured of the infection. There were no side effects observed from the administration of clindamycin. None of the patients developed any blood dyscrasia, liver damage, diarrhea, or colitis. Clindamycin appears to be effective in the treatment of mixed aerobic and anaerobic pleuropulmonary infections in children, alone or with an aminoglycoside when indicated.
Highlights
Aspiration pneumonia is common in pediatric clindamycin alone or combined with an aminopatients who suffer from acute or chronic neu- glycoside in the treatment of aspiration pneurological disorder which alters their conscious- monia in pediatric patients
The patients were divided according to their clinical and roentgenographic features into the following groups: (i) pneumonitis, where there was a pulmonary infiltrate with no evidence of cavitation; (ii) necrotizing pneumonia, where patients presented with multiple small pulmonary cavities less than 2 cm in diameter; (iii) pulmofor aspiration pneumonia may be difficult, if one of the causative organisms is Bacteroides fragilis
These patients presented with aspiration pneumonia where aerobic and anaerobic bacteria were isolated, but aerobic enteric gram-negative bacilli were not predominant
Summary
Twenty-eight patients with anaerobic pleuropulxnonary infections were treated with clindamycin alone or clindamycin with gentamicin. The average length of treatment was 13.8 days, and the duration of temperature after initiation of therapy was 3.1 days. All patients responded to the therapy and were cured of the infection. There were no side effects observed from the administration of clindamycin. Clindamycin appears to be effective in the treatment of mixed aerobic and anaerobic pleuropulmonary infections in children, alone or with an aminoglycoside when indicated. Aspiration pneumonia is common in pediatric clindamycin alone or combined with an aminopatients who suffer from acute or chronic neu- glycoside in the treatment of aspiration pneurological disorder which alters their conscious- monia in pediatric patients. The aerobic and anaerobic bacteriology of such in-
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